tolerance to opiates is regulated by a number of substances including nmda inhibitors, calcium channel blockers, magnesium and zinc. studies have shown that intrathecal administration of magnesium and zinc can slow the development of opiate tolerance buildup. but is this ever used clinically? is there a regiment of drugs given to patients on opiates to keep their tolerance low? finally, would oral zinc and magnesium supplements have the same effect?

Filed under: Magnesium

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